| Paper Abstract and Keywords |
| Presentation |
2013-03-15 16:50
Distance Distribution Analysis in Pockets among Amino Acids
Makiko Miyoshi, Takayuki Itoh, Kei Yura (Ochanomizujoshi Univ.) |
| Abstract |
(in Japanese) |
(See Japanese page) |
| (in English) |
Protein is the major component of the organism. It has a unique typical three-dimensional structure determined by the sequence of, amino acids. A hole (pocket) on the surface of a protein is known to be the best target for a drug to react. We started analyzing how "druggability" of proteins related to the locations amino acids in a pocket. For a starter of this study, this paper presents a visualization tool for distance distribution analysis between two types of amino acids in a pocket. When protein surface is provided by triangular meshes, this tool first identifies a pocket from the protein surface, specifies the deepest position of the pockets, and calculates distances between atoms of an amino acid and the deepest positions of the pocket. This tool then visualizes the distribution of the distances by scatterplots. This paper proposes the a biological interpretation of the visualization results. |
| Keyword |
(in Japanese) |
(See Japanese page) |
| (in English) |
Visualization / Protein / Amino acid / Distance distribution analysis / Pocket identification / / / |
| Reference Info. |
ITE Tech. Rep., vol. 37, pp. 243-246, March 2013. |
| Paper # |
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| Date of Issue |
2013-03-08 (AIT) |
| ISSN |
Print edition: ISSN 1342-6893 |
| Download PDF |
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| Conference Information |
| Committee |
AIT IIEEJ AS |
| Conference Date |
2013-03-15 - 2013-03-15 |
| Place (in Japanese) |
(See Japanese page) |
| Place (in English) |
Keio Univ. |
| Topics (in Japanese) |
(See Japanese page) |
| Topics (in English) |
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| Paper Information |
| Registration To |
AS |
| Conference Code |
2013-03-AIT-IIEEJ-AS |
| Language |
Japanese |
| Title (in Japanese) |
(See Japanese page) |
| Sub Title (in Japanese) |
(See Japanese page) |
| Title (in English) |
Distance Distribution Analysis in Pockets among Amino Acids |
| Sub Title (in English) |
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| Keyword(1) |
Visualization |
| Keyword(2) |
Protein |
| Keyword(3) |
Amino acid |
| Keyword(4) |
Distance distribution analysis |
| Keyword(5) |
Pocket identification |
| Keyword(6) |
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| Keyword(7) |
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| Keyword(8) |
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| 1st Author's Name |
Makiko Miyoshi |
| 1st Author's Affiliation |
Ochanomizujosi University (Ochanomizujoshi Univ.) |
| 2nd Author's Name |
Takayuki Itoh |
| 2nd Author's Affiliation |
Ochanomizujosi University (Ochanomizujoshi Univ.) |
| 3rd Author's Name |
Kei Yura |
| 3rd Author's Affiliation |
Ochanomizujosi University (Ochanomizujoshi Univ.) |
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| Speaker |
Author-1 |
| Date Time |
2013-03-15 16:50:00 |
| Presentation Time |
90 minutes |
| Registration for |
AS |
| Paper # |
AIT2013-110 |
| Volume (vol) |
vol.37 |
| Number (no) |
no.17 |
| Page |
pp.243-246 |
| #Pages |
4 |
| Date of Issue |
2013-03-08 (AIT) |